Tunisian troops killed four suspected Islamist militants in a counter-terrorism operation overnight that continued through to Tuesday, the interior ministry spokesperson said.
Kasserine province, which neighbours Algeria, has seen repeated clashes between security forces and Islamist militants.
Last month, a suspected militant was kiolled in an exchange of fire in the Mount Mghila area of the province.
Islamist militants have killed dozens of police and soldiers since the 2011 revolution that ousted longtime dictator Zine El Abidine Ben Ali.
Several attacks had often been claimed by Al-Qaeda in the Islamic Maghreb. Last year however, the Islamic State jihadist group claimed attacks on the national museum in Tunis and a popular resort hotel, killing a total of 59 tourists, and the suicide bombing of a bus that killed 12 presidential guards.
The attacks, which have dealt a heavy blow to Tunisia’s tourism-reliant economy, are believed to have been organised from neighbouring Libya, where US aircraft carried out a deadly strike on their suspected mastermind last month.